目的：探讨IL-17 基因rs2275913 多态性与胃癌易感性的关系。方法：检索多个国内外数据库，收集有关IL-17 基因G>A 多态性位点rs2275913（G197A） 与胃癌易感性的病例- 对照研究。筛选文献、提取数据和文献质量评价后，采用STATA 12.1 统计软件进行Meta 分析。结果：最终纳入10 个病例- 对照研究，其中病例组4 371 例，对照组5 345 例。Meta 分析结果显示，IL-17 基因rs2275913 位点多态性的等位基因模型（A vs. G）（OR=1.22，95% CI=1.10~1.37）与相加模型（AA vs. GG）（OR=1.58，95% CI=1.23~2.04）胃癌风险增加，显性模型（AG+GG vs. AA）（OR=0.63，95% CI=0.48~0.84）、隐性模型（GG vs. AG+AA）（OR=0.86，95% CI=0.78~0.94）胃癌风险降低（均P<0.05），但共显性模型（AG vs. AA+GG）（OR=0.91，95% CI=0.78~1.07）与罹患胃癌的风险无明显关系（P>0.05）。结论：IL-17 基因rs2275913 多态性的与胃癌易感性密切相关。
Association between rs2275913 polymorphism in IL-17 gene and gastric cancer susceptibility: a Meta-analysis
Objective: To investigate the association between rs2275913 site polymorphism of IL-17 gene and the risk of gastric cancer. Methods: The case-control studies on relationship between the IL-17 rs2275913 G>A polymorphism and gastric cancer susceptibility were collected by searching several national and international databases. After literature screening, data extraction and quality assessment, Meta-analysis was performed by STATA 12.1 software. Results: Ten case-control studies were finally included, with 4 371 patients in case group and 5 345 subjects in control group. Meta-analysis results showed that among the rs2275913 site polymorphisms of IL-17 gene, the risk of gastric cancer was increased under allele-contrast model (A vs. G) (OR=1.22, 95% CI=1.10–1.37) and additive model (AA vs. GG) (OR=1.58, 95% CI=1.23–2.04), and was decreased under dominant model (AG+GG vs. AA) (OR=0.63, 95% CI=0.48–0.84) and recessive model (GG vs. AG+AA) (OR=0.86, 95% CI=0.78–0.94), but had no obvious change under codominant model (AG vs. AA+GG) (OR=0.91, 95% CI=0.78–1.07). Conclusion: IL-17 rs2275913 polymorphism is closely related to gastric cancer susceptibility.