胃黏膜肠上皮化生（IM）普遍认为是胃腺癌多阶段发生模式的中间阶段，已被视为癌前病变。IM 有多种发病因素，且有越来越多的分子被证实参与了其发生机制。流行病学证据显示IM 可能具有可逆性，但是目前仍存在争议。笔者就IM 的病因、分子机制、是否可逆等方面等研究进展综述文献。
Research progress in intestinal metaplasia of the gastric mucosa
Gastric intestinal metaplasia (IM) is generally believed an intermediate stage in the multistep process of gastric adenocarcinoma, and considered as precancerous lesion. IM has multiple pathogenic factors, and many molecules have been found involved in the mechanisms for its occurrence. Epidemiological evidence showed the possibility of reversibility in IM, but it is still controversial at present. The authors address, in this paper, the research progress in respects of causes, molecular mechanism and reversibility of IM.