目的：比较超声刀与传统电刀用于乳腺癌术中乳房组织切除、腋窝淋巴结清扫的疗效。方法：检索国内外数据库，收集相关随机对照试验（RCT），行文献筛选、质量评价和资料提取后，应用RevMan 5.2 软件完成Meta 分析。结果：共纳入8 个RCT，总样本量604 例，其中超声刀组300 例，电刀组304 例。Meta 分析结果显示，与电刀组比较，超声刀组手术时间无明显差异（WMD=6.20，95% CI=-5.02~17.41，P=0.28），但术中出血量（WMD=-61.42，95% CI=-83.76~-39.09）、术后引流量（WMD=-374.92，95% CI=-453.90~-295.95）、引流时间（WMD=-3.30，95% CI=-5.10~-1.49）、术后皮下积液发生率（RR=0.51，95% CI=0.38~0.68）均明显降低（均P<0.05）。结论：乳腺癌手术中，使用超声刀在控制术中出血量、减少术后引流、降低术后皮下积液方面优于电刀。
Ultrasonic scalpel versus electrocautery in breast cancer surgery: a Meta-analysis
Objective: To compare the efficacy of ultrasonic scalpel and traditional electrocautery for mastectomy and axillary lymph node dissection in breast cancer surgery. Methods: The relevant randomized controlled trials (RTCs) were collected by searching the national and international databases. After literature screening, quality assessment and data extraction, Meta-analysis was performed by using RevMan 5.2 software. Results: Eight RTCs were finally included, with a total sample size of 604 cases comprising 300 cases in ultrasonic scalpel group and 304 cases in electrocautery group. Results of Meta-analysis showed that in ultrasonic scalpel group compared with electrocautery group, the operative time had no significant difference (WMD=6.20, 95% CI=-5.02–17.41, P=0.28), but the intraoperative blood loss (WMD=–61.42, 95% CI=–83.76––39.09), postoperative drainage volume (WMD=–374.92, 95% CI=–453.90––295.95), drainage time (WMD=–3.30, 95% CI=–5.10––1.49), and the incidence of subcutaneous fluid collection (RR=0.51, 95% CI=0.38–0.68) were all significantly decreased (all P<0.05). Conclusion: In breast cancer surgery, use of ultrasonic scalpel is superior to that of electrocautery in respects of intraoperative bleeding control, and reducing postoperative drainage and incidence of subcutaneous fluid collection.