目的：探讨乳腺癌钙化的相关危险因素。方法：回顾性分析2012—2014 年经病理确诊的196 例乳腺癌患者的临床病理及影像学资料，采用单因素分析及Logistic 回归，分析临床病理因素与钙化之间的关系。结果：196 例患者中，钙化140 例（71%），非钙化56 例（29%）。单因素分析显示，淋巴结转移、TNM 分期、病理类型、HER-2 与钙化有关（均P<0.05）。Logistic 回归分析显示，病理类型（OR=0.299，95% CI=0.134~0.665）、肿瘤直径（OR=2.436，95% CI=1.108~5.357）、HER-2（OR=2.827，95% CI=1.363~5.864）是乳腺癌钙化的影响因素（均P<0.05）；浸润性导管癌钙化的风险是导管原位癌的0.299倍，肿瘤直径>2 cm 钙化的风险是≤ 2 cm 的2.436 倍，HER-2 阳性患者钙化风险是HER-2 阴性患者的2.827 倍。单纯性钙化在肿瘤直径≤ 2 cm、导管原位癌和HER-2 阳性患者中构成比增高，而钙化合并肿块在浸润性导管癌和肿瘤直径>2 cm 的患者中的构成比高于其他钙化类型（均P<0.05）。结论：导管原位癌、肿瘤直径>2 cm 和HER-2 阳性是乳腺癌钙化的主要危险因素。
Risk factor analysis for calcification in breast carcinoma
Objective: To determine the risk factors for calcification in breast cancer. Methods: The clinicopathologic and imaging data of 196 patients with pathologically confirmed breast cancer between 2012 and 2014 by pathological diagnosis were retrospectively analyzed. The relations of clinicopathologic factors with breast calcification were determined by univariate and multivariate Logistic regression analysis. Results: In 196 patients, 140 cases (71%) had breast calcification and 56 cases (29%) had no breast calcification. Univariate analysis showed that lymph node metastasis, TNM stage, pathological type, and HER-2 status were associated with calcification (all P<0.05). Multivariate Logistic regression analysis revealed that pathological type (OR=0.299, 95% CI=0.134–0.665), tumor diameter (OR=2.436, 95% CI=1.108–5.357), and HER-2 expression (OR=2.827, 95% CI=1.363–5.864) were inferential factors for calcification (all P<0.05), and the calcification risk of invasive ductal carcinoma (IDC) was 0.299-fold that of ductal carcinoma in situ (DCIS), tumor ≥2 cm was 2.436-fold that of tumor <2 cm, positive HER-2 expression was 2.827-fold that of negative HER-2 expression. The constituent ratio of simple calcification was increased in patients with tumor size ≤2 cm, DCIS or HER-2 positive expression, and the constituent ratio of calcification with mass was higher than other calcification types in patients with IDC or tumor size >2 cm (all P<0.05). Conclusion: DCIS, HER-2 expression and tumor diameter are main risk factors for calcification in breast cancer.