乳腺肿瘤专题研究(Monographic Study of Breast Tumors)

同时性双侧乳腺癌与异时性双侧乳腺癌预后差异的Meta 分析

Published at: 2015年第24卷第11期

霍金龙 1 , 杨伟明 1 , 明亚芳 1
1 遵义医学院附属医院 甲乳外科,贵州 遵义 563000
通讯作者 伟明 杨 Email: yangweiming2004@126.com
DOI: 10.3978/j.issn.1005-6947.10.3978/j.issn.1005-6947.2015.11.013
基金:
贵州省科学技术基金资助项目 黔科合J 子[2011]2271 号
贵州省遵义市红花岗区科技局基金资助项目 遵红 科合社字[2013]13 号

摘要

目的:系统评价同时性双侧乳腺癌(SBBC)与异时性双侧乳腺癌(ABBC)预后差异。方法:计算机检索国内外数据库,收集相关文献,经文献筛选、质量评价和资料提取后,对符合纳入标准的研究采用Revman 5.3 软件进行Meta 分析。结果:共纳入7 个研究,共711 例患者,其中SBBC 患者225 例,ABBC 患者486 例。Meta 分析结果显示,SBBC 患者组1、5、10 年生存率均明显低于ABBC 患者(OR=0.41,95% CI=0.22~0.77,P=0.005;OR=0.52,95% CI=0.39~0.69,P<0.00001;OR=0.43,95% CI=0.25~0.74,P=0.003)。结论:在同等医疗条件下,SBBC 的预后可能差于ABBC,但仍需作进一步的完整评估。


Prognostic difference of synchronous versus asynchronous bilateral breast cancer: a Meta-analysis

Abstract

Objective: To systematically assess the prognostic difference between synchronous bilateral breast cancer (SBBC) and asynchronous bilateral breast cancer (ABBC). Methods: The relevant studies were collected by searching the national and international online databases. After literature screening, quality assessment and data extraction, Meta-analysis was performed by using RevMan 5.3 software. Results: Seven studies were finally included, involving 711 patients, with 225 SBBC cases and 486 ABBC cases. The results of Meta-analysis showed that the 1-, 5- and 10-year survival rates in SBBC patients were significantly lower than those in ABBC patients (OR=0.41, 95% CI=0.22–0.77, P=0.005; OR=0.52, 95% CI=0.39–0.69, P<0.00001; OR=0.43, 95% CI=0.25–0.74, P=0.003). Conclusion: The prognosis of SBBC is probably poorer than that of ABBC under the same medical circums and, however, further complete evaluation remains to be done.


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引用

引用本文: 金龙 霍, 伟明 杨, 亚芳 明. 同时性双侧乳腺癌与异时性双侧乳腺癌预后差异的Meta 分析[J]. 中国普通外科杂志, 2015, 24(11): 1565-1570.
Cite this article as: HUO Jinlong, YANG Weiming, MING Yafang . Prognostic difference of synchronous versus asynchronous bilateral breast cancer: a Meta-analysis[J]. Chin J Gen Surg, 2015, 24(11): 1565-1570.