目的：评价吲哚菁绿（ICG）荧光技术应用于乳腺癌前哨淋巴结活检（SLNB）的可行性。方法：选择2010 年11 月—2012 年2 月期间68 例乳腺癌患者，其中36 例以ICG 荧光导航技术进行SLNB（ICG 组），32 例应用美蓝为示踪剂行SLNB（染料组）。所有患者SLNB 结束后行I、II 水平腋窝淋巴清扫。结果：两组基本临床资料差异无统计学意义（均P>0.05），具有可比性。ICG 组前哨淋巴结（SLN）检出率为97.2%（35/36），染料组为81.3%（26/32），前者明显高于后者（P<0.05）。假阴性率与每例患者平均检测SLN 数量两组间差异无统计学意义（均P>0.05)。结论：用ICG 荧光导航技术行乳腺癌SLNB，其检出率高于染料法，且同时具备核素、染料示踪剂的替代选择。
Application of indocyanine green fluorescence navigation in sentinel lymph node biopsy for breast cancer
Objective: To evaluate the feasibility of using indocyanine green (ICG) fluorescence technique in sentinel lymph node biopsy (SLNB) for breast cancer. Methods: Sixty-eight breast cancer patients admitted between November 2010 and February 2012 were selected. Of the patients, 36 cases underwent SLNB with ICG fluorescence navigation (ICG group), while 32 cases underwent SLNB using methylene blue as a tracer (dye group). All patients received level I and II axillary dissection after the SLNB. Results: The baseline clinical data between the two groups had no statistical difference (all P>0.05), and were comparable. The detection rate of sentinel lymph nodes (SLNs) was 97.2% (35/36) in ICG group and 81.3% (26/32) in dye group, and the former was significantly higher than the latter (P<0.05). There was no significant difference in false-negative rate and mean number of excised SLNs between the two groups (both P>0.05). Conclusion: The detection rate of using ICG fluorescence navigation SLNB for breast cancer is higher than that of dye tracer, and it can be used as an alternative option for radioactive or dye tracer.