临床研究(Clinical Research)

我国HER-2阳性乳腺癌预后影响因素的Meta分析

Published at: 2016年第25卷第2期

郭晨明 1 , 吴楠 1 , 郭丽英 1
1 新疆医科大学第一附属医院 乳腺外科,新疆 乌鲁木齐 830054
通讯作者 丽英 郭 Email: 617302240@qq.com
DOI: 10.3978/j.issn.1005-6947.10.3978/j.issn.1005-6947.2016.02.018
基金:
新疆重大疾病医学重点实验室专项基金资助项目 SKLI-XJMDR-ZX-2014-1

摘要

目的:系统评价影响HER-2阳性乳腺癌预后的因素。方法:检索国内公开发表的关于HER-2阳性乳腺癌预后相关的文献,依据纳入标准和排除标准,纳入符合要求的文献,并提取相应观测指标的5年生存率,利用Revman 5.3软件行Meta分析。结果:纳入4篇文献。558例患者纳入研究。各指标5年生存率的Meta结果显示,年龄≥35岁患者优于年龄<35岁患者(OR=0.01,95% CI=0.01~0.02,P<0.00001)、无家族史的优于有家族史的患者(OR=0.00,95% CI=0.00~0.00,P<0.00001)、肿瘤<5 cm的患者优于肿瘤≥5 cm的患者(OR=14.83,95% CI=1.03~212.53,P=0.05)、无淋巴结转移的患者优于有淋巴结转移的患者(OR=0.47,95% CI=0.27~0.82,P=0.007)、组织学分级为I、II级的患者优于分级为III级的患者(OR=2.84,95% CI=1.63~4.97,P=0.0002)、病理分型为其他癌的患者优于病理分型为浸润性导管癌的患者(OR=35.5,95% CI=21.71~58.03,P<0.00001);绝经状态对患者预后无明显影响(OR=0.64,95% CI= 0.26~1.59,P=0.34)。结论:年龄、家族史、肿瘤大小、淋巴结转移、组织学分级、病理分型与HER-2阳性乳腺癌预后有关。绝经状态对预后的影响有待进一步证明。


Prognostic factors for HER-2-positive breast cancer in China: a Meta-analysis

Abstract

Objective: To systematically assess the factors that influence the prognosis of HER-2-positive breast cancer. Methods: Publicly published domestic studies regarding the prognosis of HER-2-positive breast cancer were searched, and the eligible studies were selected based on the inclusion and exclusion criteria, and then the 5-year survival rates for different observational factors were extracted and Meta-analysis was performed by RevMan 5.3 software. Results: A total of 4 studies with 558 patients were included. Results of Meta-analysis for different observational factors showed that the 5-year survival rate in patients ≥35 years of age was better than that in those <35 years of age (OR=0.01, 95% CI=0.01–0.02, P<0.00001), in patients without family history was better than those with a family history (OR=0.00, 95% CI=0.00–0.00, P<0.00001), in patients with tumor size < 5 cm was better that those with tumor size ≥5 cm (OR=14.83, 95% CI=1.03–212.53, P=0.05), in patients without lymph node metastasis was better than in those with lymph node metastasis (OR=0.47, 95% CI=0.27–0.82, P=0.007), in patients with histological grade I or II was better than in those with histological grade III (OR=2.84, 95% CI=1.63–4.97, P=0.0002), and in patients with other pathological types was better than in those with invasive ductal carcinoma (OR=35.5, 95% CI=21.71–58.03, P<0.00001); the menopausal status had no significant influence on prognosis of the patients (OR=0.64, 95% CI=0.26–1.59, P=0.34). Conclusion: Age, family history, tumor size, lymph node metastasis, histological grade and pathological type are associated with the prognosis of HER-2-positive breast cancer, but the influence of menopausal status on prognosis remains to be identified.


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引用

引用本文: 晨明 郭, 楠 吴, 丽英 郭. 我国HER-2阳性乳腺癌预后影响因素的Meta分析[J]. 中国普通外科杂志, 2016, 25(2): 264-270.
Cite this article as: GUO Chenming, WU Nan, GUO Liying . Prognostic factors for HER-2-positive breast cancer in China: a Meta-analysis [J]. Chin J Gen Surg, 2016, 25(2): 264-270.