目的：探讨广州地区年轻胃癌患者（≤ 40 岁）发病的危险因素。 方法：采用以医院为基础的1:1 病例对照研究。病例组为59 例≤ 40 岁的胃癌患者，对照组为59 例 ≤ 40 岁的排除胃癌的健康人群，自行设计问卷采访获取研究对象的个人情况、饮食习惯、生活方式、 遗传因素、既往病史、幽门螺杆菌（Hp）感染及心理因素等，应用条件Logistic 回归模型进行单因素 和多因素分析筛选胃癌发病的危险因素。 结果：多因素条件Logistic 回归分析显示，进食煎炸烧烤食品（OR=3.552，95% CI=1.066~11.840）、 进食腌制食品（OR=4.067，95% CI=1.171~14.127）、酗酒（OR=11.369，95% CI=1.029~125.589）、 慢性胃炎胃溃疡病史（OR=6.500，95% CI=1.625~25.996）、一级亲属胃癌家族史（OR=29.664， 95% CI=2.368~371.576）、A 型血（OR=4.962，95% CI=1.344~18.320）、Hp 感染（OR=8.376， 95% CI=2.035~34.470）及情绪低落或压抑（OR=7.981，95% CI=1.098~58.020）等为年轻胃癌发病 的危险因素（均P<0.05）。 结论：广州地区年轻胃癌发病与多种因素有关，具有以上因素者，应改变饮食习惯与生活方式、警惕 胃癌的发生。
Risk factors for gastric cancer in young people in Guangzhou area: a case-control study
Objective: To investigate the risk factors for gastric cancer in young people under 40 years of age in Guangzhou area. Methods: A hospital-based case-control study with 1:1 matching was carried out, which enrolled 59 gastric cancer patients ≤40 years old in case group and 59 healthy adults ≤40 years of age in whom gastric cancer could be excluded were in control group. A self-designed questionnaire was used to obtain information on demographics, dietary habit, lifestyle, genetic factors, medical history, helicobacter pylori (Hp) infection and psychological factors from the subjects, and then the risk factors for gastric cancer were screened by univariate and multivariate conditional Logistic regression analysis. Results: Multivariate conditional Logistic regression analysis showed that fried or grilled food consumption (OR=3.552, 95% CI=1.066–11.840), pickled food consumption (OR=4.067, 95% CI=1.171–14.127), excessive drinking (OR=11.369, 95% CI=1.029–125.589), history of chronic gastritis and peptic ulcers (OR=6.500, 95% CI=1.625–25.996), history of gastric cancer in the first-degree relative (OR=29.664, 95% CI=2.368–371.576), type A blood (OR=4.962, 95% CI=1.344–18.320), Hp infection (OR=8.376, 95% CI=2.035–34.470) and low mood or depression (OR=7.981, 95% CI=1.098–58.020) were risk factors for occurrence of gastric cancer in young people (all P<0.05). Conclusion: Occurrence of gastric cancer in young people in Guangzhou area is associated with a number of factors, and those who have the above risk factors should change their eating habits and lifestyle behaviors, and be vigilant in preventing the occurrence of gastric cancer.