文献综述(Review)

ADAM10、ADAM17的作用和miRNA的调节在腹主动脉瘤发病机制中的研究进展

Published at: 2016年第25卷第6期

焦通 1 , 姚野 1 , 孙庆峰 1 , 庄俊丽 1 , 张博 1 , 王云鹏 1 , 王海洋 1
1 哈尔滨医科大学附属第一医院群力院区 血管外科,黑龙江 哈尔滨 150001
通讯作者 海洋 王 Email: wanghaiyangguan@163.com
DOI: 10.3978/j.issn.1005-6947.10.3978/j.issn.1005-6947.2016.06.023
基金:
国家自然科学基金资助项目 81570424
科技部国际合作项目 2011DFR50070
黑龙江省自然科学基金资助项目 H201344

摘要

腹主动脉瘤(AAA)是一种病死率极高的急症,因发病机制复杂,至今病因尚未明确。近年来研究发现,去整合素和金属蛋白酶(ADAM)家族参与促进炎性因子的释放、细胞外基质降解等特性可能与AAA发病有关;miRNA在血管平滑肌细胞中特异性表达并通过信号通路调节其增殖和凋亡、靶向调控炎性细胞分化和炎性因子的释放、调节细胞外基质蛋白表达等可能也参与调节AAA发病。笔者就ADAM10和ADAM17在AAA发病机制中作用和miRNA对AAA发病调节做一综述。


Actions of ADAM10 and ADAM17 and regulatory role of miRNAs in pathogenesis of abdominal aortic aneurysm

Abstract

Abdominal aortic aneurysm (AAA) is an urgent clinical condition with high mortality, and its pathogenesis is complicated and has not been elucidated so far. Recent investigations found that the features of participation of a disintegrin and metalloprotease (ADAM) family in inflammatory factor release and degradation of extracellular matrix suggest their involvement in the onset of AAA; miRNAs may also play regulatory roles in occurrence of AAA, because of their specific expression in vascular smooth muscle cells (VSMCs), regulating the proliferation and apoptosis of the VSMCs through the signaling pathways, targeted regulation of inflammatory cell differentiation and the release of inflammatory cytokines, and regulating extracelluar matrix protein expressions. The authors, in this paper, address the actions of ADAM10 and ADAM17 in AAA and the regulatory mechanisms of miRNAs in the pathogenesis of AAA.


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引用

引用本文: 通 焦, 野 姚, 庆峰 孙, 俊丽 庄, 博 张, 云鹏 王, 海洋 王. ADAM10、ADAM17的作用和miRNA的调节在腹主动脉瘤发病机制中的研究进展[J]. 中国普通外科杂志, 2016, 25(6): 908-912.
Cite this article as: JIAO Tong, YAO Ye, SUN Qingfeng, ZHUANG Junli, ZHANG Bo, WANG Yunpeng, WANG Haiyang . Actions of ADAM10 and ADAM17 and regulatory role of miRNAs in pathogenesis of abdominal aortic aneurysm[J]. Chin J Gen Surg, 2016, 25(6): 908-912.