目的：综合定量评价甲状腺微小癌（TMC）淋巴转移的危险因素，为TMC的治疗及转移风险评估提供依据。方法：检索相关数据库，收集国内外2005年1月―2015年7月发表的关于TMC淋巴转移危险因素的研究进行Meta分析。结果：共纳入文献12篇，共3 355例患者，发生淋巴转移1 292例（38.51%）。Meta分析结果显示，低年龄（OR=1.46，95% CI=1.20~1.78）、男性（OR=2.26，95% CI=1.65~3.09）、肿瘤直径≥0.5 cm（OR=0.46，95% CI=0.36~0.59）、原发灶多灶（OR=0.52，95% CI=0.42~0.65）、发生囊外侵袭（OR=3.22，95% CI=2.04~5.08）是TMC淋巴转移的危险因素（均P<0.05）。结论：对于年龄<45岁、男性、肿瘤直径≥0.5 cm、原发灶多灶、发生囊外侵袭的TMC患者应警惕淋巴转移的发生。
Risk factors for lymphatic metastasis of thyroid microcarcinoma: a Meta-analysis
Objective: To systematically evaluate the risk factors for lymphatic metastasis of thyroid microcarcinoma (TMC), and provide a basis for its treatment and assessment of metastatic risk. Methods: Studies published from January 2005 to July 2015 in domestic and international journals concerning the risk factors for lymphatic metastasis of TMC were collected by searching relevant databases, and then Meta-analysis was performed. Results: A total of 12 studies were included, involving 3 355 patients, of whom 1 292 cases (38.51%) had lymphatic metastasis. Results of Meta-analysis showed that young age (OR=1.46, 95% CI=1.20−1.78), male sex (OR=2.26, 95% CI=1.65−3.09), tumor size larger than 0.5 cm (OR=0.46, 95% CI=0.36−0.59), multiple primary lesions (OR=0.52, 95% CI=0.42−0.65), and presence of extracapsular invasion (OR=3.22, 95% CI=2.04−5.08) were risk factors for lymphatic metastasis of TMC (all P<0.05). Conclusion: TMC patients with age <45 years, male gender, tumor diameter ≥0.5 cm, multiple primary lesions, or presence of extracapsular invasion, should be vigilant of lymphatic metastasis.