Clinicopathologic characteristics of thyroid carcinoma with concomitant lymphocytic thyroiditis: analysis of 129 cases
Objective: To investigate the clinicopathologic characteristics of thyroid carcinoma (TC) with concomitant lymphocytic thyroiditis (LT). Methods: The clinical data of 87 patients with TC alone (TC group) and 129 patients with TC and concomitant LT (TC plus LC group) were retrospectively analyzed, and the latter included 40 cases had concomitant Hashimoto's thyroiditis (HT), 81 cases had concomitant chronic lymphocytic thyroiditis (CLT) and 8 cases had concomitant HT and CLT. Results: All patients received surgical treatment that included unilateral thyroid lobectomy, and sub-total or total thyroidectomy with lymph node dissection of different scopes according to the disease conditions of the patients. In patients with TC and concomitant LT, only one case (0.8%) was medullary thyroid carcinoma (MTC), and all the remaining cases were papillary thyroid carcinoma (PTC). In TC plus LC group compared with TC group, the proportions of female gender, microcarcinoma, unilateral lobe involvement and negative cervical lymph node were significantly increased, while the maximum diameter of tumor was significantly decreased (all P<0.05). Among patients in TC plus LC group, there was no significant difference in any studied clinicopathologic variables between cases with concomitant HT and concomitant CLT (all P>0.05). Conclusion: TC that coexists with LT is dominated by PTC, and the majority of cases are female gender. LT may possibly inhibit metastasis of TC within the gland and to the lymph nodes, and the clinicopathologic features are similar between TC combined with CLT and TC combined with HT.