目的：探讨术中注射纳米碳混悬液在甲状腺乳头状癌中央区淋巴清扫手术中的临床价值。方法：回顾性分析270例甲状腺乳头状癌连续病例的临床和病理资料，其中70例（78侧）术中注射纳米碳混悬液（观察组），200例（215侧）未注射（对照组），所有标本行病理检查。结果：两组患者基本临床病理资料无统计学差异（均P>0.05），具有可比性；观察组和对照组检出淋巴结总数分别为475枚和790枚，观察组平均每侧检出淋巴结数多于对照组（5.50 vs. 3.00，P<0.01），但两组间合并淋巴细胞甲状腺炎患者检出淋巴结数差异无统计学意义（6.00 vs. 4.50，P>0.05）；观察组染色淋巴结转移率低于未染色淋巴结（21.67% vs. 39.15%，χ2=17.250，P<0.01）。结论：纳米碳可增加甲状腺乳头状癌手术中央区淋巴结检出数量，但对于合并淋巴细胞甲状腺炎患者可能作用有限。
Application of carbon nanoparticles in central neck dissection for papillary thyroid carcinoma
Objective: To investigate the clinical value of intraoperative injection of carbon nanoparticles in central neck dissection for papillary thyroid carcinoma (PTC). Methods: The clinical and pathological data of 270 consecutive PTC patients were retrospectively analyzed. Of the patients, 70 cases (78 sides) underwent intraoperative injection of carbon nanoparticles (observation group), and the other 200 cases (215 sides) underwent conventional surgery without injection of carbon nanoparticles (control group). Routine pathological examination was performed in all resected specimens. Results: The basic clinicopathologic data showed no significant difference between the two groups of patients (all P>0.05), and were comparable. The total number of detected lymph nodes was 475 and 790 in observation group and control group, respectively. The average number of detected lymph nodes for each side in observation group was greater than that in control group (5.50 vs. 3.00, P<0.01), but that showed no significant difference between the two groups in patients with lymphocytic thyroiditis (6.00 vs. 4.50, P>0.05). The metastatic rate in the black-stained lymph nodes was less than that in those without staining in observation group (21.67% vs. 39.15%, χ2=17.250, P<0.01). Conclusion: Carbon nanoparticle injection can increase the number of lymph node detection during central neck dissection for papillary thyroid cancer, but the value is limited in patients with lymphocytic thyroiditis.