基础研究(Basic Research)

TGF-α与EGFR在继发性甲状旁腺功能亢进症腺体组织中的表达及意义

Published at: 2016年第25卷第11期

朱珠 1 , 陶庆松 2 , 嵇振岭 2
1 江苏省苏州科技城医院 普通外科,江苏 苏州 215000
2 东南大学附属中大医院 普外二科,江苏 南京 210000
通讯作者 庆松 陶 Email: tqs123zhuzhu@163.com
DOI: 10.3978/j.issn.1005-6947.10.3978/j.issn.1005-6947.2016.11.013
基金:

摘要

目的:探讨转化生长因子α(TGF-α)与表皮生长因子受体(EGFR)在继发性甲状旁腺功能亢进症(SHPT)患者甲状旁腺腺体组织中的表达及意义。方法:收集36例SHPT组织标本以及7例正常甲状旁腺组织标本,HE染色区分弥漫性增生和结节性增生甲状旁腺,用免疫组化法检测所有甲状旁腺组织中TGF-α、EGFR和Ki-67的表达,并分析TGF-α、EGFR表达与SHPT患者临床病理因素的关系。结果:36例SHPT中弥漫性增生17例,结节性增生19例,甲状旁腺的增生类型与患者的年龄、性别、透析时间、术前甲状旁腺激素水平、血钙、血磷、钙磷乘积、血清白蛋白、血红蛋白、尿素氮、肌酐和碱性磷酸酶水平均无明显关系(均P>0.05),TGF-α、EGFR、Ki-67的表达在正常甲状旁腺织、弥漫性增生甲状旁腺织、结节性增生甲状旁腺织中均依次明显升高(均P<0.05)。结论:TGF-α与EGFR在SHPT患者腺体组织中表达增高,且与甲状旁腺细胞的增生方式密切有关。


Expressions of EGFR and TGF-α in parathyroid gland tissue of patients with secondary hyperparathyroidism and their significance

Abstract

Objective: To investigate the expressions of transforming growth factor α (TGF-α) and epidermal growth factor receptor (EGFR) in the parathyroid gland tissue of patients with secondary hyperparathyroidism (SHPT) and their significance. Methods: The tissue specimens of parathyroid gland tissue from 36 SHPT patients and 7 healthy subjects were collected. The parathyroid gland tissues with diffuse hyperplasia or nodular hyperplasia were distinguished by HE staining, the protein expressions of TGF-α, EGFR and Ki-67 in all the parathyroid gland tissues were determined by immunohistochemical staining, and the relations of TGF-α and EGFR expressions with the clinicopathologic factors of SHPT patients were analyzed. Results: Of the 36 SHPT patients, the parathyroid gland presented diffuse hyperplasia in 17 cases and nodular hyperplasia in 19 cases. The types of hyperplasia showed no significant relation with the clinicopathologic factors that included age, gender, dialysis time, preoperative parathyroid hormone level, blood levels of calcium and phosphate, calcium-phosphate product, albumin, hemoglobin, blood urea nitrogen, creatinine and alkaline phosphatase of the patients (all P>0.05). All expressions of TGF-α, EGFR and Ki-67 were significantly elevated in an increasing order in normal, diffuse and nodular hyperplastic parathyroid gland tissue (all P<0.05). Conclusion: TGF-α and EGFR expressions are increased in the parathyroid gland tissue of SHPT patients, and are closely related with the type of the hyperplasia of the parathyroid of SHPT patients.


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引用

引用本文: 珠 朱, 庆松 陶, 振岭 嵇. TGF-α与EGFR在继发性甲状旁腺功能亢进症腺体组织中的表达及意义 [J]. 中国普通外科杂志, 2016, 25(11): 1596-1601.
Cite this article as: ZHU Zhu, TAO Qingsong, JI Zhenling . Expressions of EGFR and TGF-α in parathyroid gland tissue of patients with secondary hyperparathyroidism and their significance [J]. Chin J Gen Surg, 2016, 25(11): 1596-1601.