临床研究(Clinical Research)

吲哚菁绿与纳米碳在乳腺癌前哨淋巴结活检中的对比研究

Published at: 2016年第25卷第11期

邹伟伟 1 , 白玉 1 , 王希龙 1 , 程凯 1 , 孙洪光 1 , 武孟孟 1 , 李高峰 1 , 杨振林 1
1 滨州医学院附属医院 甲状腺乳腺外科,山东 滨州 256603
通讯作者 振林 杨 Email: yzhlin@126.com
DOI: 10.3978/j.issn.1005-6947.10.3978/j.issn.1005-6947.2016.11.018
基金:
国家自然科学基金资助项目 81173601
滨州医学院科技计划资助项目 BY2013KJ06
滨州医学院科研计划与科研启动基金资助项目 BY2015KJ23

摘要

目的:比较吲哚菁绿(ICG)、纳米碳混悬注射液在乳腺癌前哨淋巴结(SLN)示踪中的应用效果。方法:选择2013年11月—2016年7月收治乳腺癌行前哨淋巴结活检(SLNB)的患者136例,其中以ICG为示踪剂者60例(ICG组),以纳米碳混悬注射液为示踪剂者76例(纳米碳组)。比较两组的相关指标。结果:两组基本临床资料差异无统计学意义(均P>0.05);ICG组与纳米碳组SLN的检出率(96.67% vs. 100%)、灵敏度(89.47% vs. 95.83%)、假阴性率(10.53% vs. 4.17%)、准确率(93.33% vs. 98.68%),组间差异均无统计学意义(均P>0.05);ICG组较纳米碳组SLN检出数目少(3.17枚vs. 3.92枚,P=0.000),但检出时间短(25.72 min vs. 49.29 min,P=0.000);年龄、体质量指数(BMI)并不影响两种方法的SLN检出率及SLNB准确率(均P>0.05)。结论:ICG与纳米碳混悬注射液示踪乳腺癌SLN具有相似的效能,并且均操作简便,便于推广实施。


Comparison of indocyanine green and carbon nanoparticles for detection of sentinel lymph nodes in breast cancer

Abstract

Objective: To compare the efficacy of indocyanine green (IGG) with that of carbon nanoparticles suspension injection for detection of sentinel lymph nodes (SLNs) in breast cancer. Methods: One-hundred and thirty-six patients with early breast cancer undergoing sentinel lymph node biopsy (SLNB) from November 2013 to July 2016 were enrolled. Of the patients, IGG was used as a tracer in 60 cases (IGG group) and carbon nanoparticles suspension injection was used in the other 76 cases (nano-carbon group). The relevant variables between the two groups were compared. Results: The general clinical data showed no statistical difference between the two group of patients (all P>0.05). Between IGG group and nano-carbon group, all the parameters that included the detection rate of the SLNs (96.67% vs. 100%), sensitivity (89.47% vs. 95.83%), accuracy (93.33% vs. 98.68%) and false negative rate (10.53% vs. 4.17%) had no statistical difference (all P>0.05). The number of detected SLNs in ICG group was less than that in nano-carbon group (3.17 vs. 3.92, P=0.000), but the time for detection in IGG group was significantly shorter than that in nano-carbon group (25.72 min vs. 49.29 min, P=0.000). Age and body mass index (BMI) did not affect the detection rate of SLNs and accuracy of SLNB of the two methods (all P>0.05). Conclusion: IGG and carbon nanoparticles suspension injection have similar efficiency for detection of SLNs in breast cancer, and both are easy and convenient to use.


comments powered by Disqus

全文

引用

引用本文: 伟伟 邹, 玉 白, 希龙 王, 凯 程, 洪光 孙, 孟孟 武, 高峰 李, 振林 杨. 吲哚菁绿与纳米碳在乳腺癌前哨淋巴结活检中的对比研究 [J]. 中国普通外科杂志, 2016, 25(11): 1627-1632.
Cite this article as: ZOU Weiwei, BAI Yu, WANG Xilong, CHENG Kai, SUN Hongguang, WU Mengmeng, LI Gaofeng, YANG Zhenlin . Comparison of indocyanine green and carbon nanoparticles for detection of sentinel lymph nodes in breast cancer [J]. Chin J Gen Surg, 2016, 25(11): 1627-1632.