目的：比较吲哚菁绿（ICG）、纳米碳混悬注射液在乳腺癌前哨淋巴结（SLN）示踪中的应用效果。方法：选择2013年11月—2016年7月收治乳腺癌行前哨淋巴结活检（SLNB）的患者136例，其中以ICG为示踪剂者60例（ICG组），以纳米碳混悬注射液为示踪剂者76例（纳米碳组）。比较两组的相关指标。结果：两组基本临床资料差异无统计学意义（均P>0.05）；ICG组与纳米碳组SLN的检出率（96.67% vs. 100%）、灵敏度（89.47% vs. 95.83%）、假阴性率（10.53% vs. 4.17%）、准确率（93.33% vs. 98.68%），组间差异均无统计学意义（均P>0.05）；ICG组较纳米碳组SLN检出数目少（3.17枚vs. 3.92枚，P=0.000），但检出时间短（25.72 min vs. 49.29 min，P=0.000）；年龄、体质量指数（BMI）并不影响两种方法的SLN检出率及SLNB准确率（均P>0.05）。结论：ICG与纳米碳混悬注射液示踪乳腺癌SLN具有相似的效能，并且均操作简便，便于推广实施。
Comparison of indocyanine green and carbon nanoparticles for detection of sentinel lymph nodes in breast cancer
Objective: To compare the efficacy of indocyanine green (IGG) with that of carbon nanoparticles suspension injection for detection of sentinel lymph nodes (SLNs) in breast cancer. Methods: One-hundred and thirty-six patients with early breast cancer undergoing sentinel lymph node biopsy (SLNB) from November 2013 to July 2016 were enrolled. Of the patients, IGG was used as a tracer in 60 cases (IGG group) and carbon nanoparticles suspension injection was used in the other 76 cases (nano-carbon group). The relevant variables between the two groups were compared. Results: The general clinical data showed no statistical diﬀerence between the two group of patients (all P>0.05). Between IGG group and nano-carbon group, all the parameters that included the detection rate of the SLNs (96.67% vs. 100%), sensitivity (89.47% vs. 95.83%), accuracy (93.33% vs. 98.68%) and false negative rate (10.53% vs. 4.17%) had no statistical difference (all P>0.05). The number of detected SLNs in ICG group was less than that in nano-carbon group (3.17 vs. 3.92, P=0.000), but the time for detection in IGG group was significantly shorter than that in nano-carbon group (25.72 min vs. 49.29 min, P=0.000). Age and body mass index (BMI) did not affect the detection rate of SLNs and accuracy of SLNB of the two methods (all P>0.05). Conclusion: IGG and carbon nanoparticles suspension injection have similar efficiency for detection of SLNs in breast cancer, and both are easy and convenient to use.