目的：应用计算机仿真的方法研究Budd-Chiari 综合征（BCS）下腔静脉隔膜生长过程中血管的血流动力学变化。方法：基于MRA 图像建立下腔静脉隔膜阻塞型BCS 血管模型，利用Ansys Fluent 软件进行血流参数仿真。结果：成功建立下腔静脉隔膜阻塞型BCS 血管模型。模型实验结果显示，在隔膜生长过程中，在下腔静脉及3 支主干肝静脉汇合处与隔膜之间有一低速区，该区域面积随隔膜的增长而逐渐变大；随着隔膜的发展，下腔静脉及肝右静脉低剪切力的区域不断扩大，而切应力变大。结论：下腔静脉隔膜的发生发展是一个缓慢变化的过程，可能与下腔静脉壁面剪切力的变化密切相关。
Numerical simulation of hemodynamics in Budd-Chiari syndrome caused by membrane obstruction of the inferior vena cava
Objective: To investigate the vascular hemodynamic changes during the formation of obstructive membrane of the inferior vena cava (IVC) in Budd-Chiari syndrome (BCS) using computer simulation methods. Methods: The vascular model of BCS caused by membranous obstruction of the IVC was established based on MRA slice images, and then numerical simulation of hemodynamic parameter changes was demonstrated by using Ansys Fluent software. Results: The vascular model of BCS with membranous obstruction of the IVC was established successfully. The results of numerical simulation experiments demonstrated that during the formation of the obstructive membrane, there was a low flow speed region between the membrane and the region of confluence of the IVC and the three main hepatic veins, which increasingly enlarged with the extension of the membrane; with the development of the membrane, the low shear stress field located close to the IVC and the right hepatic vein was continuously amplified, and moreover, the shear stress gradually increased. Conclusion: The formation and development of the obstructive membrane of the IVC is a process of slow change, which may be closely related to alterations in shear stress of the wall of IVC.