文献综述(Review)

术前放化疗在局部晚期结直肠癌患者中的应用及敏感性预测研究进展

Published at: 2017年第26卷第3期

张洪印 1 , 何文龙 2
1 天津市西青医院 普通外科,天津 300380
2 天津医科大学 公共卫生学院,天津 300000
通讯作者 文龙 何 Email: hwltme_edu@163.com
DOI: 10.3978/j.issn.1005-6947.10.3978/j.issn.1005-6947.2017.03.017
基金:

摘要

结直肠癌是常见胃肠道肿瘤之一,手术是其治疗的主要方法,但局部晚期结直肠癌患者手术耐受性较低,治疗风险以及复发可能性较大,一般通过化疗等进行治疗。术前放化疗通过有效缩小肿块、及早杀灭转移细胞从而为后续治疗提供有利条件,如今被广泛应用于临床。但术前放化疗并不适宜所有局部晚期结直肠癌患者,在临床的应用中还需根据患者自身情况进行个体化分析,需要确定其患者的敏感性。笔者对术前放化疗在局部晚期结直肠癌患者的应用研究以及敏感性预测新进展进行综述,对近年来国内外相关研究中存在的问题以及新治疗理念进行阐述,以期为临床治疗方案提供参考依据。


Advances in application of preoperative chemoradiotherapy in patients with locally advanced colorectal cancer and treatment sensitivity prediction

Abstract

Colorectal cancer is one of the common gastrointestinal tumors, for which surgery is the main treatment. However, patients with locally advanced colorectal cancer have lower tolerance to surgery, with high risk for surgery and high possibility of recurrence, and are generally treated by chemotherapy. Preoperative chemoradiotherapy can effectively reduce the tumor size and kill metastatic cells early, thereby providing favorable conditions for further treatment, so it is now widely used in clinical practice. Nevertheless, preoperative chemoradiotherapy is not suitable for all patients with advanced colorectal cancer, and its clinical application should be analyzed individually according to patients’ specific condition, and the sensitivity of the patients to this treatment should be ascertained. Here, the authors address the recent progress in research of application of preoperative chemoradiotherapy in patients with locally advanced rectal cancer and its sensitivity prediction, and discuss the existing problems in the relevant studies in China and abroad as well as new treatment concepts in recent years, so as to provide a reference for its clinical application.


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引用

引用本文: 洪印 张, 文龙 何. 术前放化疗在局部晚期结直肠癌患者中的应用及敏感性预测研究进展[J]. 中国普通外科杂志, 2017, 26(3): 380-385.
Cite this article as: ZHANG Hongyin, HE Wenlong . Advances in application of preoperative chemoradiotherapy in patients with locally advanced colorectal cancer and treatment sensitivity prediction [J]. Chin J Gen Surg, 2017, 26(3): 380-385.