目的：探讨肿瘤微环境相关因子IL-6、IL-10、CXCR7在甲状腺乳头状癌中的表达及临床意义。方法：采用免疫组织化学方法检测50例甲状腺乳头状癌、20例结节性甲状腺肿组织中IL-6、IL-10、CXCR7的表达，比较三者在两种组织中的表达差异，并分析三者与甲状腺乳头状癌临床病理因素的关系。结果：IL-6、IL-10、CXCR7蛋白在甲状腺乳头状癌中的阳性表达率均明显高于结节性甲状腺肿组（62.0% vs. 30.0%，52.0% vs. 20.0%，66.0% vs. 35.0%，均P<0.05）。甲状腺乳头状癌中IL-6、IL-10的高表达与癌灶的包膜侵犯有关（均P<0.05），CXCR7的高表达与淋巴结转移有关（P<0.05）。结论：肿瘤微环境相关因子IL-6、IL-10和CXCR7在甲状腺乳头状癌组织中表达上调，其表达水平可作为评估甲状腺乳头状癌恶性侵袭及转移参考的指标。
Expressions of tumor microenvironment-associated factors IL-6, IL-10 and chemokine receptor 7 in papillary thyroid carcinoma and their clinical significance
Objective: To investigate the expressions of tumor microenvironment-associated factors IL-6, IL-10 and chemokine receptor 7 (CXCR7) in papillary thyroid carcinoma and their significance. Methods: The expressions of IL-6, IL-10 and CXCR7 in 50 specimens of papillary thyroid carcinoma tissue and 20 specimens of nodular goiter tissue were detected by immunohistochemical staining. The expression differences of the three factors between the two types of tissues were compared, and the relations of the three factors with the clinicopathologic factors of papillary thyroid carcinoma were analyzed. Results: The positive expression rates of IL-6, IL-10 and CXCR7 in papillary thyroid carcinoma tissue were all significantly higher than those in nodular goiter tissue (62.0% vs. 30.0%, 52.0% vs. 20.0% and 66.0% vs. 35.0%, all P<0.05). In patients with papillary thyroid carcinoma, the high expression of IL-6 or IL-10 was associated with tumor capsular invasion (both P<0.05), while high expression of CXCR7 was associated with lymphatic metastasis (P<0.05). Conclusion: The expressions of tumor microenvironment-associated factors IL-6, IL-10 and CXCR7 are increased in papillary thyroid carcinoma tissue, and their expression levels can be used as reference designators for estimating the invasion and metastasis of papillary thyroid carcinoma.