目的：总结胆囊原发性腺鳞癌的临床病理特点及诊治经验。方法：回顾性分析1998 年―2012 年收治的4 例胆囊腺鳞癌患者的临床资料。结果：4 例患者中，3 例行根治性手术，1 例行姑息性手术；术后病理结果显示，癌组织中含有腺癌和 鳞癌两种成分，CK8/18 及CK5/64 阳性；4 例患者均于术后1 年内死亡，中位生存期为180 d，均死于 肿瘤复发或转移。结论：胆囊腺鳞癌非常罕见、恶性程度高、临床表现缺乏特异性，发现时分期已较晚；目前尚无有效 的治疗方法，手术仍是目前主要的治疗手段，与胆囊腺癌相比总体预后较差。
Clinical analysis of adenosquamous carcinoma of the gallbladder in 4 cases
Objective: To summarize the clinicopathologic characteristics of primary adenosquamous carcinoma of the gallbladder and its diagnosis and treatment. Methods: The clinical data of 4 patients with adenosquamous carcinoma of the gallbladder admitted from 1998 to 2012 were retrospectively analyzed. Results: Of the 4 patients, 3 cases underwent radical resection and one case underwent palliative surgery. Postoperative pathological reports showed the tumor tissues contained features of both adenocarcinoma and squamous cell carcinoma, with both CK8/18 and CK5/64 positive expressions. All the 4 patients died within one year after surgery due to tumor recurrence or metastasis, with a median survival time of 180 d. Conclusion: Adenosquamous carcinoma of the gallbladder is very rare, and characterized by high malignant potential, lack of specific clinical manifestations and often seen at advanced stages. No effective treatment is available for this condition at present, surgical treatment is still the main option, and its overall prognosis is worse than that of gallbladder adenocarcinomas.