目的：探讨结直肠癌患者术前CEA、CA19-9 浓度与临床病理特征及预后的关系。 方法：收集2007 年1 月—2008 年7 月收治并行根治性手术的356 例结直肠癌患者的临床病理资料， 分析血清CEA、CA19-9 与临床病理特征及生存率的关系。 结果：单因素分析结果显示，血清CEA 浓度升高与肿瘤浸润深度、淋巴结转移、病理类型、肝转移、 周围脏器受累有关（均P<0.05）；血清CA19-9 浓度升高与肿瘤浸润深度、腹膜转移、肝转移有关（均 P<0.05）。生存分析结果显示，血清CEA 浓度升高患者生存率低于血清CEA 浓度正常患者（P<0.05）； 血清CA19-9 浓度升高患者与血清CA19-9 浓度正常患者生存率差异无统计学意义（P>0.05）；血清 CEA、CA19-9 浓度同时升高患者与血清CEA 升高或血清CA19-9 升高患者生存率差异无统计学意义（均 P>0.05），但明显低于血清CEA、CA19-9 均正常患者（P<0.05）。 结论：血清CEA、CA19-9 浓度同时升高可能是结直肠癌的晚期事件，提示患者预后不良。
Relations of preoperative CEA and CA19-9 levels with clinicopathologic profiles and prognosis in colorectal cancer patients
Objective: To investigate the relations of CA19-9 and CEA levels with clinicopathological features and prognosis of patients with colorectal cancer. Methods: The clinicopathologic data of 356 patients with colorectal cancer undergoing radical surgery from January 2007 to July 2008 were collected. The relations of preoperative CEA and CA19-9 levels and clinicopathologic features and postoperative survival rate of the patients were analyzed. Results: Results of univariate analysis showed that the increased serum CEA level was related to depth of tumor invasion, lymph node metastasis, histological type, liver metastases, peripheral organ involvement (all P<0.05). and the increased serum CA19-9 level was associated with depth of tumor invasion, peritoneal metastasis, and liver metastasis (all P<0.05). Results of survival analysis indicated that survival rate in patients with increased serum CEA level was lower than that in those with normal serum CEA level (P<0.05); survival rate had no statistical difference between patients with increased serum CA19-9 level and normal serum CA19-9 level (P>0.05); survival rate in patients with both increased CEA and CA19-9 levels showed no statistical difference compared to those with increased serum CEA or increased serum CA19-9 level (both P>0.05), but was significantly lower than in those with both normal serum CEA and CA19-9 levels (P<0.05). Conclusion: Simultaneously increased levels of both CEA and CA19-9 is likely related to a late-stage event in colorectal cancer, which suggests an unfavorable prognosis for the patients.